Jacobs and associates in 1959 were the first to report a case of triple X syndrome and to associate this chromosome abnormality with ovarian failure. The incidence of trisomy X in newborn population is estimated to be 1 in 1,000 live born
females.
Most
of them have normal physical appearance and puberty. Therefore, the reported number of triple X females in the literature is low.
They presented with episodes of amenorrhea, elevated levels of circulating folliclestimulating hormone, luteining hormone, and decreased estrogen concentration. Primary or secondary amenorrhea and premature menopause are common accompaniments,
but
there
is no difficulty in puberty or secondary sex development. It is uncertain whether the menstrual difficulties are associated with the karyotype or the psychogenic factors. Such patients can produce, and generally there is no chromosomal
abnormality
in
their children, if they produce.
The writer experienced a case of secondary amenorrhea in a triple X female and so we reported in firstly in Korea with brief review of literature.
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